RESUMO
Background: Vesiculobullous disorders (VBDs) are extant with diverse clinical manifestations. Vesicles and bullae are fluid-filled cavities present within or beneath the epidermis. They are autoimmune blistering disorders in which autoantibodies are directed against target antigens present in the epidermis and dermo-epidermal junction. Objective: Evaluation of the various clinicodemographic profile of patients with a pattern of distribution (subtypes) of VBDs of the skin and assess the association between clinical aspects and histological changes in vesiculobullous lesions of the skin. Materials and Methods: The study material constituted 93 cases of VBDs out of 936 skin biopsies reported over two and a half years (January 2016 to June 2018) from the tertiary care center. A detailed history of the patients was taken, and a complete physical and dermatological examination with findings including clinical diagnosis was recorded. Histopathological examination (incisional/excisional/punch biopsy) was done in each case. The clinico-demographic evaluation was done and the results were correlated with histopathological findings. Results: Vesiculobullous lesions constituted 10.06% of all skin biopsies. The majority of cases were of pemphigus vulgaris (PV) 30 (32.25%) followed by 16 (17.2%) of bullous pemphigoid. In 83 cases (89.24%) histopathology findings were consistent with clinical diagnosis. Out of 34 cases that were diagnosed clinically as PV , the histopathological study proved 30 cases (88.23%) as PV. Conclusion: Vesiculobullous lesions of the skin are a heterogeneous group of disorders. It is essential to differentiate each pattern of subtype based on clinical examination and histopathological findings. Histopathological diagnosis with clinical correlation plays a major role in arriving at the diagnosis.
RESUMO
Objectives: The present study was aimed to provide data on palatal indices, and to describe the osteological and morphological variations in the grooves and bony prominences of the hard palate, and thus to compare the same with the work of other authors. Methods: 100 dry, sexed, adult human skulls were studied from sources in various Medical Colleges of Gujarat, and palatal indices were measured with Vernier callipers to the nearest 0.1 mm. The percentage frequencies of spines, crests, variant sutures, and longitudinal grooves were determined. Results: The values for Palatine index showed that 63% of the total sample of skulls had narrow (leptostaphyline), 24% had intermediate (mesostaphyline), and 13% had wide (brachystaphyline) palates; while the Palatine height index showed that 42% of the total sample had low (chamestaphyline), 54% had intermediate (orthostaphyline), and 4% had deep (hypsistaphyline) palates. Longitudinal palatal grooves were found bilaterally in all the palates, with 86.5% having crests along their length. Incisive suture was seen in 8% of the adult skulls studied. Conclusion: A knowledge of Palatal indices would be helpful to the surgeons during repair of the cleft palate and/or lip, and to anthropologists. Further, the anatomical variations in the grooves, crests and spines on the hard palate may be of clinical significance in the administration of local anaesthesia, and in palatal surgery and prosthetic dentistry.